"First published in the 1590s, the Tsenerene would go through more than two hundred editions, making it one of the most popular Yiddish books of all time. Few Ashkenazi Jewish households were without a copy." (source)

"And Isaac's grandmother has already finished the weekly Torah portion in Tsena Ve-Rena, the women's Yiddish Bible, and come and sits down outside on the stone bench in front of the house." (Only Yesterday by Shmuel Yosef Agnon)